Research: Childhood Trauma Linked With Poor Response To Lithium

Last Updated: 19 Aug 2019
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A new study suggests that surviving childhood trauma could make individuals with bipolar disorder less receptive to treatment with lithium later in life.


April 1, 2017, PARIS, France—Surviving physical abuse as a child appears to make people with bipolar disorder less likely to respond to treatment with lithium later in life, a new study suggests.

French and British researchers looked at almost 150 people with bipolar disorder currently in a stable mood. They found about 20 percent responded excellently to lithium and about half were partial responders. The other 30 per cent showed no response.

The study found that a higher level of childhood physical abuse significantly correlated with a lower level of response to lithium. In addition, a history of mixed bipolar episodes was independently associated with poor response to lithium.

The study, which appeared in the journal Acta Psychiatrica Scandinavica, was entitled “Childhood trauma and mixed episodes are associated with poor response to lithium in bipolar disorders.”

Source: http://onlinelibrary.wiley.com/doi/10.1111/acps.12684/abstract


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bp Magazine and bphope.com are dedicated to inspiring and providing information to people living with bipolar disorder and their families, caregivers, and health-care professionals. bp Magazine works to empower those diagnosed with bipolar to live healthy, fulfilling lives by delivering first-person success stories—including celebrity profiles and essays by people with lived experience—as well as informative articles addressing topics such as relationships, employment, sleep, exercise, stress reduction, mood management, treatments, and cutting-edge news and research.
2 Comments
  1. My wife just got off lithium,did not work! Childhood abuse she grew up with…yesterday went off the wall in hospital..starting over again.
    I love my wife,2 great kids this illness is devastating to her and are family..I take one day at a time.

    1. You are a good man for sticking with her and battling the disorder and not her.

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